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Showing posts with label medications. Show all posts




Treatment for atrial fibrillation, a common heart rhythm disorder, will depend on how long you've had atrial fibrillation, how bothersome your symptoms are and the underlying cause of your atrial fibrillation. Generally, the treatment goals for atrial fibrillation are to:

  • Reset the rhythm or control the rate
  • Prevent blood clots

The strategy you and your doctor choose depends on many factors, including whether you have other problems with your heart and if you're able to take medications that can control your heart rhythm.

Doctors may prescribe medications to control your heart rate or to help maintain a normal heart rhythm. In some cases, if medications aren't effective, you may need a more invasive procedure to control your heart rate.

Heart rate control

You may be prescribed medications to control your heart rate and restore it to a normal rate. Heart rate control can be achieved through several medications.

The medication digoxin (Lanoxin) may control heart rate at rest, but not as well during activity. Most people require additional or alternative medications, such as calcium channel blockers or beta blockers.

Beta blockers may cause side effects such as worsening of heart failure and low blood pressure (hypotension). Calcium channel blockers also can cause side effects and may need to be avoided if you have heart failure or low blood pressure.

Maintaining a normal heart rhythm

Your doctor may prescribe anti-arrhythmic medications to help prevent future episodes of atrial fibrillation. Medications may include:

  • Dofetilide (Tikosyn)
  • Flecainide
  • Propafenone (Rythmol)
  • Amiodarone (Cordarone, Pacerone)

Although these drugs may help maintain a normal heart rhythm, they can cause side effects, including:

  • Nausea
  • Dizziness
  • Fatigue

Rarely, they may cause ventricular arrhythmias — life-threatening rhythm disturbances originating in the heart's lower chambers. These medications may be needed indefinitely. Even with medications, the chance of another episode of atrial fibrillation is high.












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Medications to control heart rate and heart rhythm in atrial fibrillation

Several Meds Can Help People Quit Drinking: Study

But these drugs are rarely prescribed for people who abuse alcohol, experts say


WebMD News from HealthDay

Preliminary study suggests sugary sodas help

By Steven Reinberg

HealthDay Reporter

TUESDAY, May 13, 2014 (HealthDay News) -- A new review finds that several drugs can help curb the desire to drink alcohol, but the researchers note that these medications are rarely prescribed.

Acamprosate (Campral) and naltrexone (Revia), along with support from groups such as Alcoholics Anonymous or psychological counseling, can be useful tools to help people stay away from alcohol, the review authors report.

"Most people with alcohol use disorders aren't getting any treatment, and only about 10 percent are getting a medication as part of their treatment," said lead researcher Dr. Daniel Jonas, an assistant professor of medicine at the University of North Carolina at Chapel Hill.

Two other drugs, nalmefene (Selincro) and topiramate (Topamax) also can help patients stop drinking, he said. Nalmefene is approved for pain relief and topiramate is approved to prevent seizures, but they are also used "off-label" to treat alcohol abuse.

Part of the reason these medications aren't used that much is that doctors aren't sure there are drugs that work, Jonas said. "But we do have treatments that work, and we should be using them more than we are," he added.

Jonas noted that these drugs should be used along with other treatments.

"We don't know if they should be used alone. They are always studied in conjunction with a psychological intervention, whether it's AA or cognitive behavioral therapy. The standard of care is that everyone should do one of those things and then you would add medication," he said. "When you add medication, you get added benefit."

The report was published May 14 in the Journal of the American Medical Association. The U.S. Agency for Healthcare Research and Quality funded the research.

Dr. Katharine Bradley, a senior investigator at the Group Health Research Institute in Seattle and co-author of an accompanying journal editorial, said several effective medications are available to treat alcohol use disorders.

However, these medications are often not offered to patients seeking treatment for these disorders, she said.

Unlike the older medications for alcohol abuse, these newer drugs don't make people ill if they drink, Bradley explained.

"Instead, newer effective medications for alcohol use disorders address the underlying biology of addiction to alcohol, and make people less likely to drink or less likely to drink heavily if they do drink," she said.

Patients fighting alcoholism should expect, or ask, for information about medications that could help them in their battle, Bradley said.

"The decision of which alcohol treatment to choose should be the result of discussions between patients and their clinicians that take into account patient values, preferences and goals," she said.

For the new review, Jonas' team reviewed 122 studies that evaluated acamprosate, naltrexone or both. The researchers then calculated the number of people who would have to be treated with a drug to see the benefit in a single patient.

The researchers found that 12 patients would have to be given acamprosate to see a benefit from the drug in one patient. For naltrexone, it would be 20 patients.

There haven't been any head-to-head trials to see if one drug is more effective than the other, Jonas said.

For naltrexone, the researchers didn't find an association with return to some drinking or heavy drinking, but they did find an association with reduction in the number of heavy drinking days.

Alcoholism can cause damage to the liver, brain and other organs and may increase the odds of dying early threefold, the researchers said.

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Several Medications Can Help People Quit Drinking: Study



Pain medications after surgery

You don't have to endure severe pain after surgery. Modern pain medications and anesthesia can control post-surgical pain and help your body heal.

By Mayo Clinic Staff


If you're having surgery, it's natural to have concerns — or even fears — about the pain following the procedure. Some pain is common after surgery, but you shouldn't have to endure severe pain. Pain medications are a key part of your recovery. Well-controlled pain using pain medications can speed healing and lead to fewer complications.

The time to talk about post-surgical pain relief and pain medications is before you have surgery. Being prepared can lead to more effective pain management.





Planning for surgery



Here's how to start:

  • Discuss previous experiences with pain. Before surgery, talk to your doctor about your experience with different methods of pain control. Mention what worked for you and what didn't.
  • Talk about chronic pain. If you have chronic pain, you'll likely have to deal with that pain in addition to the post-surgical pain. And your body may be less sensitive to pain medication — a phenomenon called tolerance — if you're taking medications for chronic pain. Discuss this in detail with your doctor before surgery.
  • Make a list of your medications. Include all prescription and over-the-counter medications, plus any supplements or herbs you've taken in the past month. Your doctor needs to know about anything that might interact with post-surgical pain medications.
  • Be honest about your alcohol and drug use. Tell your doctor if you're a recovering alcoholic or have a history of other addiction. If so, you can plan for pain control that minimizes the risk of relapse.

    If you're currently misusing alcohol or drugs — even those that have been prescribed for you — let your doctor know. Withdrawing from these substances can be difficult, and the post-surgical period is not the time to try it.

  • Ask questions. Find out how severe the pain typically is after this type of surgery, and how long it lasts. What kind of pain medications will be given before and after surgery? What are the possible side effects of these medications? What can be done to minimize side effects?
  • Discuss your concerns about pain medications. If you're afraid of side effects or overdosing on pain medications, talk to your doctor. He or she can help you understand strategies to safely manage your pain, such as combining medications or using patient-controlled analgesia — a system that allows you to give yourself a dose of pain medication by pushing a button.

Post-surgical pain control requires balancing benefits and risks. If your pain medications are too strong, you may have side effects, such as sleepiness, nausea or vomiting. But if pain medications are too weak, you may experience unnecessary pain.

Pain limits your ability to breathe deeply, cough, walk and perform the activities necessary for a speedy recovery. The goal is finding the right balance for you at each point during and after the procedure.





Pain relief after major surgery



Doctors often rely on intravenous medications to relieve pain during and immediately after surgery. These techniques are typically used until you're able to take pain medications by mouth. The type of pain medication you receive may depend partially on the type of surgery you have because the intensity of pain and the effectiveness of certain drugs varies by surgery.

Intravenous (IV) pain medication

Before surgery, you'll probably have a slender plastic tube (catheter) inserted into a vein in your hand or arm to give you fluids, sedatives, anesthetics, antibiotics or pain medications. After surgery, your doctor may keep this IV catheter in place to deliver pain medication while you're in the hospital or outpatient recovery area.

Pain relievers, such as opioids (for example, morphine or fentanyl), are usually injected into your IV catheter at regular intervals. Most hospitals also offer patient-controlled analgesia (PCA) — a system that allows you to give yourself a fixed dose of the medication by pushing a button. This way you don't have to ask a nurse for each dose of pain medicine.

The PCA system has built-in safeguards to prevent you from overdosing on pain medication. If you push the button more than once within a set period of time, the dispenser ignores the second request. This gives each dose of pain medicine enough time to work before you receive another dose.

When there's more medication than you need in your bloodstream, you become too sleepy to press the button. When you're no longer drowsy from medication, you'll be able to safely give yourself another dose.

That's why friends or family should never push your PCA button. No one but the person receiving the medication should ever administer a dose.

Epidural analgesia

In epidural analgesia, pain medications are injected through a catheter inserted into the epidural space within your spinal canal but outside your spinal fluid. An epidural catheter is often used for labor and delivery, and sometimes before an operation, such as cesarean section or major abdominal surgery.

The epidural catheter can be left in place for several days if needed to control postoperative pain. A continuous infusion of pain relievers, including numbing medications (local anesthetics) or opioid medications, can be delivered through the catheter to control pain.

Patient-controlled epidural analgesia (PCEA), similar to PCA, enables you to give yourself an extra dose of the pain medication by pushing a button. It, too, has built-in safeguards so that you don't give yourself too much medication.

Spinal anesthesia

Some surgeries can be done with spinal anesthesia. Unlike epidural analgesia, this form of pain relief involves medications injected directly into the spinal fluid.

Spinal anesthesia is easier and faster than epidural analgesia is, but it doesn't last as long because there's no catheter to allow the administration of additional medication. Your doctor can add a long-acting opioid to the spinal medication that can relieve post-surgical pain for up to 24 hours.

Nerve block

A nerve block provides targeted pain relief to an area of your body, such as an arm or leg. It prevents pain messages from traveling up the nerve pathway to your brain. Nerve blocks can be used for outpatient procedures or more-involved inpatient surgery.

If you need only several hours of pain relief, your doctor may inject local anesthetics, such as ropivacaine (Naropin) or bupivacaine (Marcaine), directly into a wound or surgical cut, using a very small needle.

For longer pain relief, your anesthesiologist may place a catheter into that area to deliver a continuous infusion of pain medications. Sometimes you may even go home with a nerve block catheter attached to a pump that provides ongoing pain relief.

Combination pain medications

Often called multimodal pain relief, this involves receiving a combination of opioid and one or more other drugs, such as acetaminophen (Tylenol, others), ibuprofen (Advil, Motrin IB, others), celecoxib (Celebrex), ketamine (Ketalar) or gabapentin (Gralise, Neurontin). All of these medications share the ability to relieve pain, and each can be given in low enough doses to avoid side effects.

The additional drugs are usually given by mouth in tablet form. The combination may improve pain relief and reduce side effects by reducing the need for opioids.










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Pain medications after surgery

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